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SML3537

Sigma-Aldrich

CK156

≥98% (HPLC)

Synonym(s):

N-tert-Butyl-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.1²,⁶.0¹⁷,²⁰]docosa-1(20),2,4,6(22),14(21),15,18-heptaene-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H25N5O3
Molecular Weight:
395.45
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)(C)NC(C(C=C1)=C(OCCOCCNC2=N3)C=C1C4=C3N(C=C2)N=C4)=O

Biochem/physiol Actions

CK156 is a potent and selective DRAK1 inhibitor (IC50 = 49 nM by cell-free radiometric assay, IC50 = 181 nM by cellular NanoBRET, KD = 21 nM by ITC, selectivity by a 468-kinase panel) with good selectivity over DRAK2 (61% inhibition at 1 μM, IC50 = 8 μM by NanoBRET).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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