SML3330

MRK-560

≥98% (HPLC)

• Synonym(s): MRK 560, MRK560, N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
• Empirical Formula (Hill Notation): C₁₉H₁₇ClF₅NO₄S₂
• CAS Number: 677772-84-8
• Molecular Weight: 517.92
• MDL number: MFCD09970622
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+
• InChI key: WDZVWDXOIGQJIO-UJKQEGAGSA-N

Description

Biochem/physiol Actions

MRK-560 is a brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor (GSI; IC50 = 0.65 nM by SH-SY5Y cellular γ-secretase substrate A4CTF breakdown assay) with little inhibitory potency against a panel of 171 enzymes/receptors. MRK-560 blocks Aβ40 & Aβ42 production with similar potency in SH-SY5Y cultures (IC50 <0.5 nM) and lowers CNS Aβ40 in rats (brain & SCF ED50 in 8h = 6 & 10 mg/kg po.) and APP-YAC mice (brain ED50 in 4h <3 mg/kg po.) in vivo

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable