SML3050

Olsalazine sodium

• Synonym(s): Olsalazine sodium, 3,3´-Azobis(6-hydroxybenzoic acid) sodium, 5,5′-Azodisalicylic acid sodium, 5,5′-azobis(salicylic acid) sodium, C.I. Mordant Yellow 5; 3,3′-dicarboxy-4,4′-dihydroxyazobenzene sodium, azodisal sodium
• Empirical Formula (Hill Notation): C₁₄H₈N₂O₆ · 2Na
• CAS Number: 6054-98-4
• Molecular Weight: 346.20
• UNSPSC Code: 12352200
• NACRES: NA.24

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• InChI: 1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;

Description

Biochem/physiol Actions

Olsalazine is an anti-inflammatory drug used in inflammatory bowel disease and ulcerative colitis treatments. It is a pro-drug of 5-aminosalicylic acid (mesalamine) that it is converted by the bacteria in the colon to mesalamine. Olsalazine (5-aminosalicylic acid) is consider as a broad-spectrum anticancer agent. Additionally, olsalazine increases both eEF1A2 and utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable