SML2669
ITK7
≥98% (HPLC)
Synonym(s):
8-methyl-7-(prop-1-yn-1-yl)-2-((pyrimidin-2-ylthio)methyl)quinazolin-4(3H)-one
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About This Item
Empirical Formula (Hill Notation):
C17H14N4OS
CAS Number:
Molecular Weight:
322.38
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=C(N=C(CSC2=NC=CC=N2)NC3=O)C3=CC=C1C#CC
Biochem/physiol Actions
ITK7 is a cell penetrant, potent and selective inhibitor of PARP11 mono-ADP-ribosylation (MARylation) activity.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Ilsa T Kirby et al.
Cell chemical biology, 25(12), 1547-1553 (2018-10-23)
Poly-ADP-ribose polymerases (PARPs1-16) play pivotal roles in diverse cellular processes. PARPs that catalyze poly-ADP-ribosylation (PARylation) are the best characterized PARP family members because of the availability of potent and selective inhibitors for these PARPs. There has been comparatively little success in
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