SML2636
Sb4
≥98% (HPLC)
Synonym(s):
2-[[(4-Bromophenyl)methyl]thio]benzoxazole, BMP signaling agonist Sb4
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About This Item
Empirical Formula (Hill Notation):
C14H10BrNOS
CAS Number:
Molecular Weight:
320.20
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1
Biochem/physiol Actions
Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Shayna T J Bradford et al.
The Journal of biological chemistry, 294(9), 3125-3136 (2019-01-04)
Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to be protective by promoting renal repair and regeneration. Clinical use of recombinant BMPs
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