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SML1749

Sigma-Aldrich

Narasin Ready Made Solution

1 mg/ml in DMSO

Synonym(s):
(2R)-2-[(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyloxan-2-yl]butanoic acid, (4S)-4-Methylsalinomycin, A 28086A, Antibiotic A 28086A, Antibiotic C 7819B, C 7819B, Monteban, Narasin A, Narasul
Empirical Formula (Hill Notation):
C43H72O11
CAS Number:
Molecular Weight:
765.03
NACRES:
NA.77

biological source

Streptomyces aureofaciens

Quality Level

form

solution

concentration

1 mg/ml in DMSO

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1

InChI key

VHKXXVVRRDYCIK-CWCPJSEDSA-N

Biochem/physiol Actions

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. Narasin inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

In addition, Narasin inhibits Dengue virus (DENV) at the post-entry stage of viral replication during DENV infection. The inhibition of DENV involves a non-cytotoxic mechanism, therefore, Narasin can be possibly considered as therapeutic agent against DENV infection. A dose dependent curve (0.01-5 μM) showed that Narasin has 50% inhibitory concentration at less than 1 μM against all four serotypes of DENV. The IC50 (μM) of Narasin against four different DENV serotypes was 0.05-0.65 μM.

Other Notes

Narasin solution is provided at 1.307 mM (1 mg/ml). Typical final concentration for use in cell culture is 0.01-5 μM. Stable at ­­­–20 °C for at least 2 years.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Certificate of Analysis

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Certificate of Origin

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