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Key Documents

SML1509

Sigma-Aldrich

MK6-83

≥98% (HPLC)

Synonym(s):

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O2S2
CAS Number:
1062271-24-2
Molecular Weight:
336.47
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

InChI key

IRGYSXZCDAWOOC-UHFFFAOYSA-N

Biochem/physiol Actions

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient?s Survival
Morelli MB, et al.
Cancers, 11(4), 525-525 (2019)

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