SML1337

NQ301

≥98% (HPLC)

• Synonym(s): 2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione, Compound 211, NQ 301
• Empirical Formula (Hill Notation): C₂₃H₁₉N₃O · HBr
• CAS Number: 130089-98-4
• Molecular Weight: 434.33
• MDL number: MFCD00559986
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825795
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , faint red to dark red
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
• InChI: 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
• InChI key: LSQZKIQSQHZVQS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H315,H319,H335,H400
• pcodes: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable