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Key Documents

SML1060

Sigma-Aldrich

Celecoxib-NBD

≥98% (HPLC)

Synonym(s):

N-(2-((7-Nitrobenzo[c]-[1,2,5]oxadiazol-4-yl)amino)ethyl)-4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C25H20F3N7O5S
Molecular Weight:
587.53
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow to orange

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Celecoxib-NBD is a flourescent COX2-specific inhibitor. The molecule binds to, and inhibits COX2 with an IC50 of 0.19 μM, and a selectivity index of 443 for COX2 vs. COX1. Celecoxib-NBD fluorescently labels COX2-expressing HCA-7 colon cells, but not COX2-negative HCT116 cells.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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