SML0362

NPS2143 hydrochloride

≥98% (HPLC)

• Synonym(s): 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1), NPS-2143 hydrochloride, SB-262470-A hydrochloride
• Empirical Formula (Hill Notation): C₂₄H₂₅ClN₂O₂ · HCl
• CAS Number: 324523-20-8
• Molecular Weight: 445.38
• MDL number: MFCD16038896
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825364
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]20/D +20 to +24°, c = 1.0 in methanol
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
• InChI: 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
• InChI key: ZEBNDUQLNGYBNL-VEIFNGETSA-N

Description

Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

• In the regulation of intestinal calcium transport.
• In the regulation of local negative feedback of intestinal calcium absorption.
• In sensorimotor decision making during development.

Biochem/physiol Actions

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312 + H332,H410
• pcodes: P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable