SML0174

GPR35 Agonist, Compound 10

≥98% (HPLC)

• Synonym(s): 2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid
• Empirical Formula (Hill Notation): C₁₂H₉NO₅S
• CAS Number: 123021-85-2
• Molecular Weight: 279.27
• MDL number: MFCD01835940
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825204
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥5 mg/mL at ~60 °C
• storage temp.: 2-8°C
• SMILES string: OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O
• InChI: 1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5-
• InChI key: WXMCOLGPDOYHNK-UITAMQMPSA-N

Description

Application

GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies.

Biochem/physiol Actions

GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable