SMB01068

Licoricidin

≥90% (LC/MS-ELSD)

• Synonym(s): (+)-Licoricidin, 7-O-Demethyllicorisoflavan A, Licorisoflavan B
• Empirical Formula (Hill Notation): C₂₆H₃₂O₅
• CAS Number: 30508-27-1
• Molecular Weight: 424.53
• MDL number: MFCD32182601
• UNSPSC Code: 12352205
• NACRES: NA.25

Properties

• biological source: plant
• assay: ≥90% (LC/MS-ELSD)
• form: solid
• mol wt: 424.53
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• InChI: 1S/C26H32O5/c1-15(2)6-8-19-22(27)11-10-18(25(19)29)17-12-21-24(31-14-17)13-23(28)20(26(21)30-5)9-7-16(3)4/h6-7,10-11,13,17,27-29H,8-9,12,14H2,1-5H3/t17-/m0/s1
• InChI key: GBRZTUJCDFSIHM-KRWDZBQOSA-N

Description

General description

Licoricidin, also known as Licorisoflavan B, a hydroxyisoflavan and an aromatic ether, is a bioactive natural compound commonly derived from Glycyrrhiza Sp. (G. uralensis, G. inflata, and G. aspera) plants. Current research indicates that this metabolite is an inhibitor and may possess diverse biological activities, including anti-inflammatory, antitumor, antibacterial, antiangiogenic and antimetastatic properties.

Application

Licoricidin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Licoricidin is a potent anti-metastatic agent, effectively reducing the metastatic and invasive capabilities of malignant prostate cancer cells. Additionally, both Licoricidin and Licorisoflavan A exhibit strong antibacterial properties against Porphyromonas gingivalis, Prevotella intermedia, and Solobacterium moorei, with minimal inhibitory concentrations ranging from 2 to 80 µg/ml. These compounds have the potential to mitigate bacterial volatile sulfur compound (VSC) production, making them suitable for managing halitosis. Furthermore, they hold promise for novel approaches to modulate hosts′ responses in conditions involving cytokines and MMPs, such as periodontitis. Licoricidin may find application in topically applied anti-aging formulations by preventing UVA-induced photoaging through ROS scavenging, ultimately limiting MMP-1 activity.

Features and Benefits

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable