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siliconizing reagent for glass and other surfaces


Quality Level

biological source





0.68 g/cm3



storage temp.


General description

Sigmacote® is a solution of a chlorinated organopolysiloxane in heptane that readily forms a covalent, microscopically thin film on glass. The film repels water, retards the clotting of blood or plasma, and prevents surface adsorption of many basic proteins. Ready to use without dilution; reusable if kept free of moisture.


Sigmacote® has been used to prevent adhesion of the growth factors to plasticware. It has also been used to coat coverslip in order to prevent the adhesion of larval brain during squashing.

Biochem/physiol Actions

Sigmacote® is ideal for glass, ceramics and fiber optics. It is used to treat GC injection glass inserts.

Legal Information

Sigmacote is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word


Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids



Flash Point(F)

24.8 °F - closed cup

Flash Point(C)

-4 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Product Information Sheet

Quotes and Ordering

  1. What is Product SL2, Sigmacote?

    Sigmacote is a solution of an organopolysiloxane in heptane used for coating glassware. It produces a thin film on the glass surface to prevent adsorption of many proteins and to repel water. 

  2. How do I use Product SL2, Sigmacote?

    Sigmacote is ready to use on glass which must be clean and dry. Details for use can be found on our Product Information Sheet (under Documents, above).

  3. Can Product SL2, Sigmacote be used on plastics or other non-glass surfaces?

    Turbid or cloudy solutions indicate water contamination and should not be used.

  4. Can Product SL2, Sigmacote be removed from glass surfaces?

    Turbid or cloudy solutions indicate water contamination and should not be used.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Comparative analysis of satellite DNA in the Drosophila melanogaster species complex
Jagannathan M, et al.
G3 (Bethesda, Md.), g3-116 (2016)
Analysis of protein S-acylation by gas chromatography-coupled mass spectrometry using purified proteins
Sorek, Nadav and Yalovsky, Shaul
Nature Protocols, 5(5), 834-834 (2010)
Isolation of adult stem cells and their differentiation to Schwann cells
Progenitor Cells, 47-57 (2012)

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