SAB5701747

Anti-Phospho-PLC gamma 1 (PLCG1)-Y783 antibody produced in rabbit

• UNSPSC Code: 12352203
• NACRES: NA.41
• clone: polyclonal
• application: WB
• species reactivity: mouse, rat, human
• technique(s): western blot: 1:500-1:2000

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• species reactivity: mouse, rat, human
• concentration: 1.59 mg/mL
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P19174
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr783)
• Gene Information: human ... PLCG1(5335)

Description

General description

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen

A phospho specific peptide corresponding to residues surrounding Y783 of human PLC gamma 1 (PLCG1)

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable