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SAB5200112

Sigma-Aldrich

Anti-AQP4 antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(s):

Anti-AQP4, Anti-Aquaporin 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 35 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: suitable
western blot: suitable

NCBI accession no.

NP_036957.1

UniProt accession no.

P55087

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Aqp4(25293)

General description

Aquaporin 4 (AQP4) is expressed in the nervous system. The gene ID of the protein is 25293.

Specificity

Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.

Immunogen

C-terminal peptide

Biochem/physiol Actions

Aquaporin 4 (AQP4) functions as a water channel in the rat brain.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, pH 7..4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Ceccariglia et al.
Neuroscience, 274, 273-288 (2014-06-10)
Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evidenced dilation of lateral ventricles, also suggesting alterations in blood-brain
Alex J Smith et al.
Acta neuropathologica communications, 7(1), 74-74 (2019-05-10)
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to
Gökhan Akdemir et al.
Neuroscience letters, 574, 70-75 (2014-04-11)
Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes. We previously showed reduced cytotoxic brain edema with improved neurological outcome in AQP4 knockout mice in water intoxication, infection and cerebral ischemia. Here, we
Jungo Kato et al.
Biochemical and biophysical research communications, 451(4), 562-567 (2014-08-16)
Aquaporin-4 (AQP4) is a water channel protein that is predominantly expressed in astrocytes in the CNS. The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS. On the other hand, little

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