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Key Documents

SAB5200085

Sigma-Aldrich

Anti-ING1 antibody produced in rabbit

250 μg/mL, affinity isolated antibody

Synonym(s):

Anti- p47ING1a, Anti-ING1, Anti-growth inhibitor ING1, Anti-p33 ING1, Anti-p33ING1b, Anti-p47

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 33 kDa

species reactivity

mouse, human

concentration

250 μg/mL

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable

NCBI accession no.

NP_036049.2

UniProt accession no.

Q9UK53

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Ing1(26356)

General description

Inhibitor of growth-family member 1 (ING1) possesses plant homeodomains (PHDs). The gene ID of the protein is 26356.

Specificity

Detects a ~33 kDa protein corresponding to the molecular mass of p33 ING1 on SDS PAGE immunoblots.

Immunogen

Mouse p33 ING1 N-terminal peptide –KLH conjugates

Biochem/physiol Actions

Inhibitor of growth-family member 1 (ING1) may take part in chromatin remodeling. It is a part of histone acetyltransferase complex and acts as an epigenetic modulator. Like the other members of its family, ING1 also functions as a tumor suppressor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

TBS, 50% glycerol, 0.09% sodium azide

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Masato Takahashi et al.
Cancer research, 62(8), 2203-2209 (2002-04-17)
The candidate tumor suppressor p33(ING1) plays an important role in inducinggrowth arrest at G(0)-G(1) phase of the cell cycle and/or promoting apoptosis in cancerous cells. p33(ING1) is reported to act as a transcriptional cofactor by associating with tumor suppressor p53
Uma Karthika Rajarajacholan et al.
PLoS biology, 11(3), e1001502-e1001502 (2013-03-09)
The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor increases >10-fold during replicative senescence. ING1a overexpression

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