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Key Documents

SAB5200074

Sigma-Aldrich

Monoclonal Anti-SCN2A1 antibody produced in mouse

clone S69-3, 1 mg/mL, purified immunoglobulin

Synonym(s):

Anti-NachII, Anti-Nav1.2, Anti-Nav1.2, S69-3, Anti-SCN, Anti-SCN2A, Anti-Scpll

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S69-3, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 250 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_036779.1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Scn2a1(24766)

General description

Sodium voltage-gated channel α subunit 2 (SCN2A1) is expressed in the axons and nerve terminals of the rat brain. The gene ID for the protein is 24766.

Specificity

Detects ~250 kDa.

Immunogen

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Monoclonal anti-SCN2A1 antibody produced in mouse has been used for immunofluorescence and Western blotting.

Biochem/physiol Actions

Sodium voltage-gated channel α subunit 2 (SCN2A1) may associate with a number of other proteins in the rat brain. It regulates the conductance of action potentials and also controls the release of neurotransmitters.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Norelle C Wildburger et al.
Molecular & cellular proteomics : MCP, 14(5), 1288-1300 (2015-03-01)
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse
Je-Hyun Baek et al.
The Journal of biological chemistry, 289(22), 15363-15373 (2014-04-17)
Voltage-gated sodium (Nav) channels initiate action potentials in brain neurons and are primary therapeutic targets for anti-epileptic drugs controlling neuronal hyperexcitability in epilepsy. The molecular mechanisms underlying abnormal Nav channel expression, localization, and function during development of epilepsy are poorly
Jun Xiang et al.
Molecular medicine reports, 9(1), 16-22 (2013-11-14)
In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn

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