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Key Documents

SAB4700555

Sigma-Aldrich

Monoclonal Anti-Cd3e-FITC antibody produced in hamster

clone 145-2C11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CD3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.44

biological source

hamster

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

145-2C11, monoclonal

form

buffered aqueous solution

species reactivity

mouse

concentration

0.5 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG

NCBI accession no.

NM_007648.4

UniProt accession no.

P22646

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

mouse ... Cd3e(12501)

Related Categories

General description

The hamster monoclonal antibody 145-2C11 reacts with mouse CD3 (epsilon subunit). This antibody is commonly used as a phenotypic marker for mouse T cells.

Immunogen

Mouse BM10-37 cytotoxic T lymphocytes

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P Sempé et al.
Diabetologia, 37(4), 337-343 (1994-04-01)
The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely
W R Han et al.
Transplant immunology, 7(4), 207-213 (2000-01-19)
In order to reduce the toxic effects of the T cell activating anti-CD3 monoclonal antibody, 145-2C11, F(ab')2 fragments were prepared by pepsin digestion. These fragments were then used as non-immunosuppressive carriers for the cytotoxic drug idarubicin (IDA), to reduce toxicity

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