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Key Documents

SAB4504313

Sigma-Aldrich

Anti-phospho-Period Circadian Protein 2 (pSer662) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 136 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

O15055

UniProt accession no.

O15055

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer662)

Gene Information

human ... PER2(8864)

General description

The PER2 (period circadian regulator 2) gene is mapped to human chromosome 2q37.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662.

Immunogen Range: 636-685

Biochem/physiol Actions

PER2 (period circadian regulator 2) possess a physiological and pathological control over the mammalian circadian clock. Abnormal expression of PER2 gene leads to the development of a variety of cancer. Loss of PER2 gene function is observed in the onset of oral squamous cell carcinoma. PER2 might act as an essential biomarker for the same. The reciprocal negative regulation loop of PER2 modulates hepatic circadian clock and the process of aging. PER2 is associated with the pathogenesis of rheumatoid arthritis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
111223

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PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility
Lee H, et al.
Molecular Medicine Reports, 16(1), 422-428 (2017)
The multiple facets of Per2
Cold Spring Harbor Symposia on Quantitative Biology, 72, 95-104 (2007)
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
Wang RH, et al.
Scientific Reports, 6(1), 28633-28633 (2016)
Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer
Xiong H, et al.
International Journal of Oncology, 52(1), 279-287 (2018)

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