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Key Documents

SAB4503087

Sigma-Aldrich

Anti-WASP antibody produced in rabbit

affinity isolated antibody

Synonym(s):

IMD2, WAS, Wiskott-Aldrich syndrome protein, Wiskott-Aldrich syndrome protein homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P42768

UniProt accession no.

P42768

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... WAS(7454)

General description

Anti-WASP Antibody detects endogenous levels of total WASP protein.
WASP (Wiskott-Aldrich syndrome protein) codes for a 65 kDa protein, localized to the cytoplasm. The WASP gene is mapped to human chromosome Xp11.23.

Immunogen

The antiserum was produced against synthesized peptide derived from human WASP.

Immunogen Range: 256-305

Biochem/physiol Actions

WASP (Wiskott-Aldrich syndrome protein) is regarded as a scaffold protein that integrates cell surface signals to actin cytoskeleton. WASP gene regulates actin polymerization, contributing to T-cell activation and migration. Neural WASP is known to regulate a variety of cellular processes including pathogen infection, vesicle trafficking, invadopodium formation and growth, and neurite extension. Mutation in this gene causes WAS, a X-linked recessive immunodeficiency disorder.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
Jain N, et al.
Scientific Reports, 5, 15031-15031 (2015)
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion
Frugtniet BA, et al.
BMC Cancer, 17(1), 224-224 (2017)
X-Linked Syndrome of Polyendocrinopathy, Immune Dysfunction, and Diarrhea Maps to Xp11.23-Xq13.3
Bennett CL, et al.
American Journal of Human Genetics, 66(2), 461-468 (2000)
Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature.
Eghbali M, et al.
Allergologia et Immunopathologia, 44(5), 450-454 (2016)
Noah Joseph et al.
FEBS letters, 588(21), 3808-3815 (2014-09-15)
The Nck adapter protein is involved in key cellular functions, such as actin polymerization and reorganization, serving as a molecular bridge between the surface complex essential for foreign antigen recognition, the T-cell antigen receptor (TCR), and the actin machinery. However

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