SAB4502441
Anti-TMEPA antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Solid tumor-associated 1 protein
Sign Into View Organizational & Contract Pricing
All Photos(3)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 31 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TMEPA(56937)
General description
Anti-TMEPA Antibody detects endogenous levels of total TMEPA protein.
The transmembrane prostate androgen-induced RNA (TMEPAI), also known as prostate transmembrane protein androgen induced 1 (PMEPA1) gene, spans 55-60 kb on human chromosome 20q13.31-q13.33. The encoded protein is mainly expressed in prostate gland and is regulated by androgen receptor (AR). TMEPAI is a type Ib transmembrane protein characterized with two PY motifs involved in binding HECT(homologous to the E6AP carboxyl terminus)-type E3 ubiquitin ligases.
Immunogen
The antiserum was produced against synthesized peptide derived from human TMEPA.
Immunogen Range: 101-150
Immunogen Range: 101-150
Biochem/physiol Actions
Transmembrane prostate androgen-induced RNA (TMEPAI)/ prostate transmembrane protein androgen induced 1 (PMEPA1) plays a vital role in maintaining prostate homeostasis. It is also implicated in p53-mediated apoptosis and cell growth inhibition.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Wei Wu et al.
International journal of cancer, 143(9), 2213-2224 (2018-05-16)
TGF-β plays a central role in mediating epithelial-mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF-β-induced EMT is NF-κB-dependent in various cancer types. However, it is largely unclear if NF-κB mediates TGF-β-induced EMT in
TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling
Watanabe Y, et al.
Molecular Cell, 37(1), 123-134 (2010)
Transmembrane prostate androgen-induced protein 1 (PMEPA1) promotes the migration and maintains mesenchymal-like phenotype of breast cancer cells
Zou Y, et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(2), 158-162 (2016)
Shashwat Sharad et al.
Epigenetics, 9(6), 918-927 (2014-04-04)
The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR). AR protein levels are controlled by the AR-PMEPA1 negative feedback loop through NEDD4-E3
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service