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Key Documents

SAB4301061

Sigma-Aldrich

Anti-INTS1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

INT1, NET28

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

concentration

1.3 mg/mL

technique(s)

immunohistochemistry: 1:25- 1:100

isotype

IgG

accession no.

NP_001073922.2

UniProt accession no.

Q8N201

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... INTS1(26173)

Specificity

The antibody detects endogenous levels of total INTS1 protein.

Immunogen

Synthetic peptide corresponding to residues near the N terminal of human integrator complex subunit 1

Application

Anti-INTS1 antibody produced in rabbit is suitable for immunohistochemistry studies at a dilution of 1:25 - 1:100.

Biochem/physiol Actions

INTS1 (Integrator complex subunit 1), a large nuclear protein, involved in the processing of small nuclear RNA as a major component of the Integrator complex. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes such as the formation of a scaffold for the assembly of integrator complex.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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David Baillat et al.
Cell, 123(2), 265-276 (2005-10-22)
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is an essential component of transcriptional regulation and RNA processing of protein-coding genes. A large body of data also implicates the CTD in the transcription and processing of RNAPII-mediated small nuclear
Toshiyuki Hata et al.
Biochimica et biophysica acta, 1773(7), 1039-1051 (2007-06-05)
The KIAA1440 protein contains no significant domains that allow for a prediction of its function, despite the fact that it is an extremely large protein comprising 2222 amino acids. In our current study, we show that the developing KIAA1440(-/-) mouse

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