SAB4300781

Anti-SLCO1B1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): LST-1, Liver-specific organic anion transporter 1, OATP 2, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 76 kDa
• species reactivity: human
• concentration: 1.0 mg/mL
• technique(s): western blot: 1:500-1:3000 (Cell Lysate)
• isotype: IgG
• accession no.: NP_006437.3
• UniProt accession no.: Q9Y6L6
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLCO1B1(10599)

Description

General description

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) or liver-specific organic anion transporter 1 (LST-1) and sodium-independent organic anion-transporting polypeptide 2 (OATP-2), is formerly known as solute carrier family 21 (organic anion transporter), member 6 (SLC21A6). SLCO1B1 is predominantly expressed in liver. It is expressed in the basolateral membrane. It has 12 transmembrane domains. In human chromosome, the gene SLCO1B1 is localized on 12p12.1

Specificity

The antibody detects endogenous levels of total SLCO1B1 protein.

Immunogen

Synthesized peptide derived from internal of human SLCO1B1.

Biochem/physiol Actions

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) transports taurocholate, conjugated steroids, eicosanoids, and thyroid hormones, in a sodium independent manner. SLCO1B1 is the key transporter of bile for the clearance of human liver. Polymorphism in SLCO1B1 might lead to life threatening drug toxicities. Mutations in SLCO1B1 and SLCO1B3 leads to rotor syndrome in human, affecting conjugated bilirubin reuptake in liver. Genetic variability in SLCO1B1 affects the plasma concentration of statins.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable