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  • S2626
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S2626

Sigma-Aldrich

Spermidine

≥99% (GC)

Synonym(s):
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
Molecular Weight:
145.25
Beilstein:
1698591
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic

Quality Level

Assay

≥99% (GC)

form

solid or liquid (clear)

impurities

DNase, none detected
RNase, none detected
protease, none detected

refractive index

n20/D 1.479 (lit.)

mp

22-25 °C

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

density

0.925 g/mL at 25 °C (lit.)

storage temp.

room temp

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
85558S250185580
Spermidine ≥99% (GC)

Sigma-Aldrich

S2626

Spermidine

Spermidine BioUltra, for molecular biology, ≥99.5% (GC)

Sigma-Aldrich

85558

Spermidine

Spermidine trihydrochloride ≥99.0% (AT)

SAFC

85580

Spermidine trihydrochloride

biological source

synthetic

biological source

-

biological source

microbial, synthetic

biological source

microbial, synthetic

assay

≥99% (GC)

assay

≥99.5% (GC)

assay

≥98% (TLC)

assay

≥99.0% (AT)

form

solid or liquid (clear)

form

-

form

powder

form

powder

impurities

DNase, none detected, RNase, none detected, protease, none detected

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

impurities

-

impurities

-

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

room temp

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.

Application

Spermidine has been used:
  • in the preparation of 5x transcription buffer
  • in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
  • as a standard in the analytical study of rat brain polyamines (185)

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Other Notes

Store under inert gas. Air sensitive; strongly hygroscopic.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

233.6 °F - closed cup

Flash Point(C)

112 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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