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Key Documents

PLA0045

Goat anti-ATM Antibody, Affinity Purified

Name: Goat anti-ATM Antibody, Affinity Purified
Brand: SIGMA

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Synonym(s):

A-T mutated, AT mutated, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A; C and D), homolog, homolog (S. cerevisiae), telomere maintenance 1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

goat

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000

accession no.

NP_000042.2

UniProt accession no.

Q13315

shipped in

wet ice

storage temp.

2-8°C

Gene Information

goat ... ATM(472)

Immunogen

The epitope recognized by PLA0045 maps to a region between residues 2550 and 2600 of human Ataxia Telangiectasia Mutated using the numbering given in entry NP_000042.2 (GeneID 472).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Hiroyasu Sakai et al.

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Wip1 (protein phosphatase Mg(2+)/Mn(2+)-dependent 1D, Ppm1d) is a nuclear serine/threonine protein phosphatase that is induced by p53 following the activation of DNA damage response (DDR) signaling. Ppm1d(-/-) mouse embryonic fibroblasts (MEFs) exhibit premature senescence under conventional culture conditions; however, little

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