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COO/COA

PLA0039

Goat anti-MCM4 Antibody, Affinity Purified

Name: Goat anti-MCM4 Antibody, Affinity Purified
Brand: SIGMA

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Synonym(s):

CDC21, CDC21 homolog, CDC54, MCM4 minichromosome maintenance deficient 4 (S. cerevisiae), MGC33310, NKCD, NKGCD, P1-Cdc21, hCdc21, homolog of S. pombe cell devision cycle 21, minichromosome maintenance deficient 4

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

goat

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

species reactivity

mouse, human

technique(s)

immunohistochemistry: 1:500-1:2,000
western blot: 1:2,000-1:10,000

accession no.

NP_005905.2

UniProt accession no.

P33991

shipped in

wet ice

storage temp.

2-8°C

Gene Information

goat ... MCM4(4173)

Immunogen

The epitope recognized by PLA0039 maps to a region between residues 325 and 375 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM4 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM4 is phosphorylated by CDC2 kinase resulting in a reduction of helicase activity and chromatin binding.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.

Spencer W Luebben et al.

Nucleic acids research, 42(9), 5605-5615 (2014-03-05)

Accumulating evidence suggests that dormant DNA replication origins play an important role in the recovery of stalled forks. However, their functional interactions with other fork recovery mechanisms have not been tested. We previously reported intrinsic activation of the Fanconi anemia

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