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Key Documents

P8953

Sigma-Aldrich

Platelet-Derived Growth Factor from porcine platelets

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

Synonym(s):

PDGF

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture

biological source

Porcine

Quality Level

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

39.00 ng/mL EC50

quality

endotoxin tested

mol wt

glycoprotein 38 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

color

white

UniProt accession no.

storage temp.

−20°C

Gene Information

Application

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Biochem/physiol Actions

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Physical form

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Analysis Note

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Articles

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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