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P5084

Sigma-Aldrich

PTIO

Synonym(s):

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide

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About This Item

Empirical Formula (Hill Notation):
C13H17N2O2
CAS Number:
18390-00-6
Molecular Weight:
233.29
MDL number:
MFCD00059929
UNSPSC Code:
12352200
PubChem Substance ID:
329820215
NACRES:
NA.32

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

Application

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Biochem/physiol Actions

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).
A stable radical scavenger for nitric oxide; affects NO without affecting NO synthase; has significant inhibitory activity against NO biological actions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Jiu-Gang Xue et al.
Journal of neurophysiology, 105(6), 2897-2906 (2011-04-08)
N-methyl-D-aspartate (NMDA) receptors (NMDARs) are implicated in synaptic plasticity and modulation of glutamatergic excitatory transmission. Effect of NMDAR activation on inhibitory GABAergic transmission remains largely unknown. Here, we report that a brief application of NMDA could induce two distinct actions
Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.
Goldstein S
The Journal of Biological Chemistry, 278 (51), 50949-50955 (2003)
Christal G Coleman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(36), 12103-12112 (2010-09-10)
Chronic intermittent hypoxia (CIH) is a concomitant of sleep apnea that produces a slowly developing chemosensory-dependent blood pressure elevation ascribed in part to NMDA receptor-dependent plasticity and reduced nitric oxide (NO) signaling in the carotid body. The hypothalamic paraventricular nucleus
Victor Parro et al.
Frontiers in microbiology, 10, 929-929 (2019-05-28)
Potential benthic habitats of early Mars lakes, probably oligotrophic, could range from hydrothermal to cold sediments. Dynamic processes in the water column (such as turbidity or UV penetration) as well as in the benthic bed (temperature gradients, turbation, or sedimentation
Victoria P A Johnstone et al.
Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)
Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.
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