Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.
synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.
Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
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