MilliporeSigma
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M9429

Sigma-Aldrich

Menadione

meets USP testing specifications

Synonym(s):
2-Methyl-1,4-naphthoquinone, Vitamin K3
Empirical Formula (Hill Notation):
C11H8O2
CAS Number:
Molecular Weight:
172.18
Beilstein:
1908453
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

Agency

USP/NF
meets USP testing specifications

Assay

98.5-101.0% dry basis

form

solid

mp

105-107 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChI key

MJVAVZPDRWSRRC-UHFFFAOYSA-N

Gene Information

human ... NQO1(1728)

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This Item
47775PHR1411M0300000
Menadione meets USP testing specifications

Sigma-Aldrich

M9429

Menadione

Menadione (K3) analytical standard

Supelco

47775

Menadione (K3)

Menadione Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1411

Menadione

Menadione European Pharmacopoeia (EP) Reference Standard

M0300000

Menadione

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

synthetic

assay

98.5-101.0% dry basis

assay

-

assay

-

assay

-

form

solid

form

-

form

-

form

solid

mp

105-107 °C (lit.)

mp

105-107 °C (lit.)

mp

105-107 °C (lit.)

mp

105-107 °C (lit.)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

-

General description

Menadione (Vitamin K3) is the synthetic form of vitamin K. It has the structure similar to vitamin K1 and K2. Vitamin K1, K2 and K3 are biologically active. Water soluble forms of menadiones are used in swine and poultry diets.

Application

Menadione has been used:
  • to treat HL-60 cells as positive control for apoptosis for flow cytometry
  • as an oxidative stress inducer in transgenic embryos after 24 h of post fertilization
  • to treat HaCaT cell line, for quantifying total and oxidised glutathione

Biochem/physiol Actions

Menadione is an oxidative stress inducer.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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