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M266

Sigma-Aldrich

Anti-Glutamate Receptor NMDAR2C (NR2C) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-GluN2C, Anti-NMDAR2C, Anti-NR2C

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About This Item

MDL number:
MFCD01865098
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen 140 kDa (NR2C subunit)
antigen 180 kDa (NR2A and NR2B bands)

species reactivity

rat, human, mouse

technique(s)

immunohistochemistry (frozen sections): 1:1000
immunoprecipitation (IP): 3 μL using 200 μg of rat cerebellum.
indirect immunofluorescence: 1:1000 using frozen sections
western blot: 1:1000 using 200 μg cell lysate

UniProt accession no.

Q14957

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRIN2C(2905)
mouse ... Grin2c(14813)
rat ... Grin2c(24411)

Immunogen

N-terminal portion of NR2C (amino acids 25-130)

Physical form

Lyophilized from ammonium bicarbonate (5 mM).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Luke A Esposito
Methods in molecular biology (Clifton, N.J.), 670, 71-84 (2010-10-23)
The accumulation of the amyloid-β (Aβ) peptide in the form of insoluble fibrillar deposits and soluble oligomeric aggregates is widely believed to play a causal role in Alzheimer's disease (AD). Proteolytic cleavage of APP by the β-site APP cleaving enzyme
Michele Buddle et al.
Brain research, 978(1-2), 38-50 (2003-07-02)
MAP2 (microtubule-associated protein 2) is a cytoskeletal phosphoprotein that regulates the dynamic assembly characteristics of microtubules and appears to provide scaffolding for organelle distribution into the dendrites and for the localization of signal transduction apparatus in dendrites, particularly near spines.
Stéphane Peineau et al.
Methods in molecular biology (Clifton, N.J.), 1677, 253-263 (2017-10-08)
Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The
K K Yung
Neuroreport, 9(7), 1639-1644 (1998-06-19)
Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A-C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR1 alpha was detected in laminae I-III of the dorsal horn, whilst mGluR2/3
H Monyer et al.
Science (New York, N.Y.), 256(5060), 1217-1221 (1992-05-22)
The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A

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