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M0883

Sigma-Aldrich

4-Methylumbelliferyl acetate

esterase substrate

Synonym(s):

MU-Ac

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About This Item

Empirical Formula (Hill Notation):
C12H10O4
CAS Number:
2747-05-9
Molecular Weight:
218.21
Beilstein/REAXYS Number:
189667
EC Number:
220-386-6
MDL number:
MFCD00006865
UNSPSC Code:
12352204
PubChem Substance ID:
24896576
NACRES:
NA.32

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

149-150 °C (lit.)

solubility

chloroform: 100 mg/mL, clear, colorless

fluorescence

λex 312 nm in methanol
λex 360 nm; λem 499 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3

InChI key

HXVZGASCDAGAPS-UHFFFAOYSA-N

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques.
J V Watson
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Our earlier work established a convenient assay procedure for acetoxycoumarin (AC): protein transacetylase (TA) by indirectly quantifying the activity of glutathione (GSH)-S-transferase (GST), the extent of inhibition of GST under the conditions of the assay represented TA activity. In this
David Sychantha et al.
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Streptococcus pneumoniae among other Gram-positive pathogens produces O-acetylated peptidoglycan using the enzyme OatA. This process occurs through the transfer of an acetyl group from a donor to the hydroxyl group of an acceptor sugar. While it has been established that
A A Frimer et al.
Free radical biology & medicine, 20(6), 843-852 (1996-01-01)
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H G Raj et al.
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Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects
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