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K4268

Sigma-Aldrich

PKCμ, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

PKCM, PKD, PRKCM

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

578-782 nmol/min·mg

mol wt

~131 kDa

UniProt accession no.

Q15139

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRKD1(5587)

General description

Protein kinase C μ (PKCμ) belongs to the protein kinase C (PKC) family. PKCμ is widely expressed with the highest expression in the thymus, lung and peripheral blood mononuclear cells.

Biochem/physiol Actions

Protein kinase C μ (PKCμ) associates with phosphatidylinositol 4-kinase as well as phosphatidylinositol-4-phosphate 5-kinase. A region of PKCμ between the amino-terminal transmembrane domain and the pleckstrin homology domain is shown to be involved in the association with the lipid kinases.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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K Nishikawa et al.
The Journal of biological chemistry, 273(36), 23126-23133 (1998-08-29)
Protein kinase Cmu (PKCmu), also named protein kinase D, is an unusual member of the PKC family that has a putative transmembrane domain and pleckstrin homology domain. This enzyme has a substrate specificity distinct from other PKC isoforms (Nishikawa, K.
J Rennecke et al.
European journal of biochemistry, 242(2), 428-432 (1996-12-01)
13 murine tissues and 12 cell lines were tested for the expression of the novel protein kinase C (PKC) isoenzyme mu. Using two different PKC mu antibodies (sc-639 and P26720), PKC mu was detected in all tissues and cells and

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