MilliporeSigma
All Photos(1)

K3761

Sigma-Aldrich

KT 5720

≥98% (HPLC), powder

Synonym(s):
(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
Empirical Formula (Hill Notation):
C32H31N3O5
CAS Number:
Molecular Weight:
537.61
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

microbial

assay

≥98% (HPLC)

form

powder

color

white to faint yellow

solubility

methanol: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

InChI key

ZHEHVZXPFVXKEY-IKZDWWSZSA-N

Looking for similar products? Visit Product Comparison Guide

Application

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Biochem/physiol Actions

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Yi-hung CHEN et al.
Acta pharmacologica Sinica, 31(12), 1553-1563 (2010-11-03)
to investigate the effects of 2'-hydroxy-4'-methoxyacetophenone (paeonol) on the electrophysiological behavior of a central neuron (right parietal 4; RP4) of the giant African snail (Achatina fulica Ferussac). intracellular recordings and the two-electrode voltage clamp method were used to study the
Swidbert R Ott et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(7), E381-E387 (2011-12-21)
The mechanisms that integrate genetic and environmental information to coordinate the expression of complex phenotypes are little understood. We investigated the role of two protein kinases (PKs) in the population density-dependent transition to gregarious behavior that underlies swarm formation in
Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer
Luo H, et al.
Journal of Experimental & Clinical Cancer Research, 30(1), 6-6 (2011)
Gustavo Tenorio et al.
Learning & memory (Cold Spring Harbor, N.Y.), 17(12), 627-638 (2010-11-26)
The capacity for long-term changes in synaptic efficacy can be altered by prior synaptic activity, a process known as "metaplasticity." Activation of receptors for modulatory neurotransmitters can trigger downstream signaling cascades that persist beyond initial receptor activation and may thus
Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
Ishida E, et al.
PLoS ONE, 7(12), e50918-e50918 (2012)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service