K0765
Anti-Potassium Channel Kv11.2 (erg2) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-KCNH6, Anti-ether-a-go-go-related channel 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
immunohistochemistry: suitable
western blot: 1:200 using rat brain and rat cortex lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Kcnh6(116745)
General description
The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6), also referred to as erg2, encodes a subunit of ether-à-go-go related (erg) K+ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K+ channels. The encoded protein is found to be expressed in the rat retina. The three isoforms erg1, erg2, and erg3 are found to be expressed in the brain. They are strongly expressed in the olfactory bulb.
Immunogen
peptide TLNFVEFNLEKHRS(C), corresponding to residues 185- 198 of human Kv11.2 located in N-terminal part of human Kv11.2.
Biochem/physiol Actions
The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6) encodes a voltage gated K+ channel that modulates the membrane potential in its rested and activated state. It may participate in the tweaking of the presynaptic membrane potential, thereby regulating neurotransmitter release.
Target description
Potassium Channel KV11.2 (erg2) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Kv11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel Kv11.1. The expression of Kv11.2 seems to be limited to the brain and the pituitary gland.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Reconstitution
Reconstitute with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Certificates of Analysis (COA)
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Fast erg K+ currents in rat embryonic serotonergic neurones.
Hirdes W
The Journal of Physiology, 564, 33-49 (2005)
Jürgen R Schwarz et al.
Journal of cellular and molecular medicine, 8(1), 22-30 (2004-04-20)
Ether-à-go-go-related gene (erg) channels are voltage-dependent K+ channels mediating inward-rectifying K+ currents because of their peculiar gating kinetics. These characteristics are essential for repolarization of the cardiac action potential. Inherited and acquired malfunctioning of erg channels may lead to the
Sönke Cordeiro et al.
PloS one, 6(12), e29490-e29490 (2011-12-30)
In response to light, most retinal neurons exhibit gradual changes in membrane potential. Therefore K+ channels that mediate threshold currents are well-suited for the fine-tuning of signal transduction. In the present study we demonstrate the expression of the different Kv11
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