I7151
Anti-Insulin-Like Growth Factor-I Receptor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-IGF-I R
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IGF1R(3480)
General description
Insulin-Like Growth Factor-I Receptor (IGF-I receptor) is a disulfide-linked heterotetrameric transmembrane protein that belongs to Tyr protein kinase family and is expressed mainly in all cells and tissues. Association of two α (130 kD) and two β (95 kD) subunits of IGF-I receptor is essential for receptor autophosphorylation. It has a pivotal role in cell growth control as well as can induce differentiation, and eventually cell death, of certain types of cells. Anti-Insulin-Like Growth Factor-I Receptor antibody can be used to block cell surface IGF-I sR mediated IGF-I and IGF-II bioactivity. Goat anti-Insulin-Like Growth Factor-I Receptor antibody reacts specifically with recombinant human IGF-I. The product has shown no cross-reactivity for other cytokines tested.
Specificity
The antibody blocks cell surface IGF-I R mediated IGF-I and IGF-II biological activity. At optimal antibody concentration, no more than 40-60% of the IGF-I or IGF-II activity can be blocked by this antibody.
Immunogen
Recombinant human IGF-I soluble receptor expressed in Sf 21.
Application
Anti-Insulin-Like Growth Factor-I Receptor antibody can be used in indirect ELISA and western blotting.
Physical form
Lyophilized from 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R C Baxter et al.
Progress in growth factor research, 1(1), 49-68 (1989-01-01)
Binding proteins for the insulin-like growth factors (IGF-I and IGF-II) are increasingly being recognized as modulators of IGF actions in both inhibitory and stimulatory ways. At least three distinct classes of binding protein are thought to exist, differing in their
The somatomedin-insulin-like growth factors.
K Hall et al.
Journal of internal medicine, 225(1), 47-54 (1989-01-01)
S E Tollefsen et al.
Biochemistry, 30(1), 48-54 (1991-01-08)
We have recently found that association of the two alpha beta dimers of the insulin-like growth factor I (IGF I) receptor is required for formation of a high-affinity binding site for IGF I [Tollefsen, S. E., & Thompson, K. (1988)
R Baserga
Experimental cell research, 253(1), 1-6 (1999-12-02)
The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in
A M Abbott et al.
The Journal of biological chemistry, 267(15), 10759-10763 (1992-05-25)
The insulin-like growth factor I (IGF I) receptor is a tyrosine kinase-containing transmembrane protein that plays an important role in cell growth control. We have isolated and characterized human genomic DNA clones containing the entire coding sequence of the IGF
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