I1783
Anti-phospho-Insulin Receptor (IR) (pTyr972) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
phosphorylation (pTyr972)
Gene Information
human ... INSRR(3645)
mouse ... Insr(16337)
General description
The biological effects of insulin are mediated by insulin receptor (IR) and IGF-1 receptor. Insulin receptor consists of two α and two β subunits, each subunit has a tyrosine kinase domain. Signaling by IR is important in cell proliferation and metabolism of glucose. Insulin receptor activates the PI3K/Akt and the FKHR pathway, thereby regulates metabolism and insulin-dependent gene expression. Tyrosine 972 is an autophosphorylation site that is present in the juxtamembrane domain. Phosphorylation at Tyr972 is required for interaction of IR with its intracellular substrates and increases the stability of IR and substrate complexes. Overexpression of IR has been observed in breast cancer tissue and is implicated in proliferation of breast cancer cells, hyperinsulinemia and insulin resistance. IR can also bind IGF-I and IGF-II with decreased affinity
Anti-phospho-IR (pTyr972) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.
Anti-phospho-IR (pTyr972) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.
Specificity
This antibody may also have cross-reactivity with phosphosphorylated insulin-like growth factor-1 receptor (IGF-1R).
Immunogen
phosphopeptide derived from the region of human insulin receptor (IR) that contains tyrosine 972.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 50% glycerol with 1 mg/ml of bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificates of Analysis (COA)
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V Papa et al.
The Journal of clinical investigation, 86(5), 1503-1510 (1990-11-01)
The growth of breast cancer cells is under the regulation of hormones, growth factors, and their receptors. In the present study, we have employed a new, sensitive, and specific radioimmunoassay for the direct measurement of insulin receptors in surgical specimens
Y Kido et al.
The Journal of clinical endocrinology and metabolism, 86(3), 972-979 (2001-03-10)
The pleiotropic actions of insulin are mediated by a single receptor tyrosine kinase. Structure/function relationships of the insulin receptor have been conclusively established, and the early steps of insulin signaling are known in some detail. A generally accepted paradigm is
V Papa et al.
Trends in endocrinology and metabolism: TEM, 8(8), 306-312 (2008-04-15)
It is commonly believed that the insulin receptor mainly mediates the metabolic effects of insulin, whereas the closely related IGF-I receptor is considered a major factor for the regulation of cell proliferation. Experimental and epidemiological evidence indicates, however, that insulin
Shailendra P Singh et al.
Journal of immunology (Baltimore, Md. : 1950), 201(5), 1491-1499 (2018-07-25)
A link between obesity and periodontitis has been suggested because of compromised immune response and chronic inflammation in obese patients. In this study, we evaluated the anti-inflammatory properties of Kavain, an extract from Piper methysticum, on Porphyromonas gingivalis-induced inflammation in
Antonino Belfiore et al.
Endocrine-related cancer, 18(4), R125-R147 (2011-05-25)
The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in
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