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I1782

Sigma-Aldrich

Inosine Monophosphate Dehydrogenase Type II human

recombinant, expressed in E. coli

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Synonym(s):
IMP:NAD oxidoreductase, IMPDH II
Enzyme Commission number:
1.1.1.205 (BRENDA, IUBMB)
MDL number:
MFCD04975063
NACRES:
NA.54

recombinant

expressed in E. coli

form

solution

specific activity

≥0.05 units/mg protein

mol wt

~55 kDa

packaging

vial of ≥0.002 unit

UniProt accession no.

P12268

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... IMPDH2(3615)

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This Item
WH0003615M1SAB1406037SAB1410715
Sigma-Aldrich

Sigma-Aldrich

I1782

Inosine Monophosphate Dehydrogenase Type II human

Monoclonal Anti-IMPDH2 antibody produced in mouse clone 1E12-B6, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

WH0003615M1

Monoclonal Anti-IMPDH2 antibody produced in mouse

Anti-IMPDH2 antibody produced in mouse purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1406037

Anti-IMPDH2 antibody produced in mouse

Anti-IMPDH2 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1410715

Anti-IMPDH2 antibody produced in rabbit

form

solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

specific activity

≥0.05 units/mg protein

specific activity

-

specific activity

-

specific activity

-

mol wt

~55 kDa

mol wt

-

mol wt

antigen ~55.8 kDa

mol wt

antigen 55.8 kDa

UniProt accession no.

P12268

UniProt accession no.

P12268

UniProt accession no.

P12268

UniProt accession no.

P12268

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

Inosine Monophosphate Dehydrogenase Type II (IMPDH2) is a ubiquitously expressed dominant isoform during developmental stages. IMPDH2 gene is mapped to human chromosome 3p21.31.

Application

Inosine Monophosphate Dehydrogenase Type II human has been used to test the inhibitory effect on vacor adenine dinucleotide (VAD) on its dehydrogenase activity.

Biochem/physiol Actions

Inosine Monophosphate Dehydrogenase Type II (IMPDH2) binds to adenosine triphosphate (ATP) and guanosine triphosphate (GTP). It catalyzes the formation of xanthosine monophosphate from inosine monophosphate in the presence of nicotinamide adenine dinucleotide (NAD). IMPDH2 elevated levels in tumors are correlated to its rate-limiting activity in guanosine monophosphate (GMP) synthesis. High levels of IMPDH2 is implicated in glioblastoma (GBM). It is regarded as a potential therapeutic target against tumors, antiviral, and immunosuppression-related pathologies.
Type II is the predominant IMPDH isoform and is specifically linked to a wide range of cancers and lymphocyte proliferation.

Unit Definition

One unit will produce 1.0 μ mole of XMP from IMP with corresponding reduction of β-NAD per minute at pH 8.0 at 25 °C.

Physical form

Solution in 20 mM Tris-HCl, pH 8.0, containing 0.5 mM EDTA and 1 mM DTT.

related product

Product No.
Description
Pricing

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Na Yang et al.
Chemical biology & drug design, 79(6), 1063-1071 (2012-03-13)
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. It is considered as an important target in the quest for drugs in the immunosuppressive, antiviral, antibacterial, and anticancer therapeutic areas. Herein, we report
Sivapriya Kirubakaran et al.
Bioorganic & medicinal chemistry letters, 22(5), 1985-1988 (2012-02-09)
Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5'-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents
Veeraraghavan Usha et al.
PloS one, 7(3), e33886-e33886 (2012-04-06)
Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified. The potential of Mycobacterium tuberculosis inosine monophosphate dehydrogenase
Flavia Schmidt et al.
Archives of toxicology, 87(2), 361-370 (2012-08-24)
Mycophenolic acid (MPA) is an immunosuppressive agent that acts as a selective, non-reversible inhibitor of the enzyme inosine-5'-monophosphate dehydrogenase (IMPDH). Malformations have been described in children after maternal exposure to mycophenolate. However, the causal link is unclear in most cases
Magdalena Makowska-Grzyska et al.
Biochemistry, 51(31), 6148-6163 (2012-07-14)
Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first unique step of the GMP branch of the purine nucleotide biosynthetic pathway. This enzyme is found in organisms of all three kingdoms. IMPDH inhibitors have broad clinical applications in cancer treatment, as antiviral
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