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Hemoglobin from bovine blood

suitable for protease substrate, substrate powder

Bovine hemoglobin, Hb, Methemoglobin
CAS Number:
MDL number:

biological source

bovine blood

Quality Level


substrate powder

mol wt

Mr ~64500


activity assay: suitable


H2O: soluble 20 mg/mL


suitable for protease substrate

UniProt accession no.

storage temp.


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General description

Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%.[25] Hemoglobin is a globular protein with α and β chains with every 141 and 146 amino acids respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme.[23]
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.


Hemoglobin from bovine blood has been used as a substrate in cathepsin D activity assay.[67][26] It has also been used to measure the activity of acid proteases (pepsin-like) in the stomach extract.[27]
The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.


25, 100 g in glass bottle
1 kg in poly drum

Biochem/physiol Actions

Bovine hemoglobin is used in the production of hemoglobin-vesicles (HbV). It has high thermal stability and high oxygen affinity when compared to human hemoglobin.[22] Bovine hemoglobin interacts with synthetic and azo dyes.[23] Polymerized forms of bovine hemoglobin are used to treat autoimmune hemolytic anemia.[31]
Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.


Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

Preparation Note

Prepared from washed, lysed and dialyzed erythrocytes.

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet


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