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GW21321

Sigma-Aldrich

Anti-RGS16 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-RGSR, Anti-Regulator of G-protein signaling 16

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-21321

technique(s)

western blot: suitable

NCBI accession no.

NP_002919.1

UniProt accession no.

O15492

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RGS16(6004)

Immunogen

Immunogen Sequence: GI # 4506513, sequence 130-202
Recombinant regulator of G-protein signalling 16

Application

Anti-RGS16 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Regulator of G-protein signaling 16 is a protein encoded by the RGS16 gene in humans and is mapped to chromosome 1q25-1q31. It is found to be expressed in 17 human gastrointestinal cancer cell lines. RGS16 expression is higher in colorectal cancer (CRC) tissue when compared to normal tissue. It can act as a predictive marker for patient prognosis of CRC. Loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Norikatsu Miyoshi et al.
Annals of surgical oncology, 16(12), 3507-3514 (2009-09-18)
The RGS family, comprising 22 homologues of proteins, plays a role in cellular proliferation, differentiation, membrane trafficking, and embryonic development through the involvement of the mitogen-activated protein kinase signaling pathway. In order to demonstrate the importance of RGS16 expression for
B E Snow et al.
Gene, 206(2), 247-253 (1998-04-04)
Regulators of G-protein signaling (RGS) constitute a family of GTPase-activating proteins with varying tissue-specific expression patterns and G-protein alpha subunit specificities. Here, we describe the molecular cloning of the human RGS-r/RGS16 cDNA, encoding a predicted polypeptide of 23kDa that shows
Genqing Liang et al.
The Journal of biological chemistry, 284(32), 21719-21727 (2009-06-11)
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway supports growth of many tumors including those of breast, lung, and prostate. Resistance of breast cancer cells to targeted chemotherapies including tyrosine kinase inhibitors (TKI) has been linked to persistent PI3K activity

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