Documents
G2536
Ganciclovir
≥99% (HPLC), powder
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Quality Level
Assay
≥99% (HPLC)
form
powder
color
white
solubility
0.1 M HCl: 10 mg/mL
ε (extinction coefficient)
12.0 at 256 nm at 1 mM
antibiotic activity spectrum
viruses
Mode of action
DNA synthesis | interferes
originator
Roche
storage temp.
2-8°C
SMILES string
NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI key
IRSCQMHQWWYFCW-UHFFFAOYSA-N
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This Item | 345700 | 1288306 | Y0001129 |
|---|---|---|---|
| form powder | form solid | form - | form - |
| color white | color white | color - | color - |
| solubility 0.1 M HCl: 10 mg/mL | solubility water: 2 mg/mL, DMSO: 5 mg/mL | solubility - | solubility - |
| originator Roche | originator - | originator - | originator - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
General description
Application
Biochem/physiol Actions
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments.
Features and Benefits
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Muta. 1B - Repr. 2
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
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