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G1013

Sigma-Aldrich

Gly-Arg 4-methoxy-β-naphthylamide dihydrochloride

dipeptidyl aminopeptidase I substrate

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About This Item

Empirical Formula (Hill Notation):
C19H26N6O3 · 2HCl
CAS Number:
100940-56-5
Molecular Weight:
459.37
MDL number:
MFCD00237896
UNSPSC Code:
12352204
PubChem Substance ID:
24895034
NACRES:
NA.32

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.COc1cc(NC(=O)C(CCCNC(N)=N)NC(=O)CN)cc2ccccc12

InChI

1S/C19H26N6O3.ClH/c1-28-16-10-13(9-12-5-2-3-6-14(12)16)24-18(27)15(25-17(26)11-20)7-4-8-23-19(21)22;/h2-3,5-6,9-10,15H,4,7-8,11,20H2,1H3,(H,24,27)(H,25,26)(H4,21,22,23);1H

InChI key

ZMJQLLSJSFQLTM-UHFFFAOYSA-N

Application

Gly-Arg 4-methoxy-β-naphthylamide dihydrochloride has been used as a substrate to measure the dipeptidyl peptidase I (DPPI) activity in human leukemia cell line.

Substrates

Substrate for dipeptidyl aminopeptidase I

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M J McGuire et al.
Archives of biochemistry and biophysics, 295(2), 280-288 (1992-06-01)
The lysosomal hydrolase, dipeptidyl peptidase I (DPPI), was purified from human spleen and its enzymatic activity characterized. The enzyme was purified to apparent homogeneity by a combination of differential pH solubility, heat-treatment, affinity chromatography on concanavalin A-agarose and p-hydroxymercuribenzoate-agarose, and

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