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EMU047501

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Atrx

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

CAAGGAAGAAGTGGGCTGAAGAATTTAATGATGAAACCAATGTGAGAGGGCGATTGTTTATCATTTCCACTAAAGCAGGATCTCTTGGAATTAACCTGGTAGCTGCTAATAGAGTGATTATATTTGATGCTTCTTGGAATCCATCTTATGACATCCAGAGTATATTCAGAGTTTATCGCTTTGGACAAACTAAGCCTGTTTATGTATATAGGTTCTTAGCTCAGGGAACCATGGAAGATAAGATTTATGATCGTCAGGTAACAAAGCAGTCACTGTCTTTCCGCGTTGTGGATCAACAGCAGGTTGAGCGCCATTTTACCATGAATGAGCTTACTGAACTTTATACTTTTGAGCCAGACTTACTAGATGACCCGAATTCAGAAAAGAAGAAGAAAAGGGATACCCCCATG

Ensembl | mouse accession no.

ENSMUSG00000031229

NCBI accession no.

NM_009530

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... ATRX(22589) , Atrx(22589)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Jennifer M Mason et al.
Cancer research, 74(13), 3546-3555 (2014-04-23)
RAD51 is the central protein that catalyzes DNA repair via homologous recombination, a process that ensures genomic stability. RAD51 protein is commonly expressed at high levels in cancer cells relative to their noncancerous precursors. High levels of RAD51 expression can
Jinquan Cai et al.
Oncotarget, 6(20), 18105-18115 (2015-05-15)
Loss of ATRX leads to epigenetic alterations, including abnormal levels of DNA methylation at repetitive elements such as telomeres in murine cells. We conducted an extensive DNA methylation and mRNA expression profile study on a cohort of 82 patients with

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