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E5627

Sigma-Aldrich

Erythropoietin human

recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein

Synonym(s):

EPO

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in CHO cells

form

lyophilized powder

specific activity

~100,000 units/mg protein

packaging

pkg of 10UN

technique(s)

cell culture | mammalian: suitable

color

white

UniProt accession no.

storage temp.

−20°C

Gene Information

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General description

Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.

Application

Erythropoietin human has been used:
  • as a component of cardiac stem cell medium
  • to test its neuroprotective effect on diabetic mice
  • to test its effect on hippocampal synapses in mice

Biochem/physiol Actions

Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions. EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies. A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia. Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.

Physical form

Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.

Analysis Note

The biological activity is assayed in tissue culture using mouse fetal liver cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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A distinct region in erythropoietin that induces immuno/inflammatory modulation and tissue protection
Yuan RR, et al.
Neurotherapeutics, 12(4), 850-861 (2015)
Concurrent isolation of 3 distinct cardiac stem cell populations from a single human heart biopsy
Monsanto MM, et al.
Circulation Research, 121(2), 113-124 (2017)
Erythropoietin decreases the excitatory neurotransmitter release probability and enhances synaptic plasticity in mice hippocampal slices
Kamal A, et al.
Brain Research, 1410, 33-37 (2011)
Erythropoietin use and abuse
John MJ, et al.
Indian Journal of Endocrinology and Metabolism, 16(2), 220-220 (2012)
Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation
Kim AR, et al.
Cell, 168(6), 1053-1064 (2017)

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