C7821
Curdlan
from Alcaligenes faecalis, ≥98% (TLC), solid
Synonym(s):
β-1,3-Glucan hydrate
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General description
Curdlan is an insoluble natural polymer with linear structure mainly produced by Alcaligenes faecalis. It is a dietary fiber with gelatin properties.
Application
Curdlan from Alcaligenes faecalis has been used:
- for the stimulation of carp macrophages for regulation of differentially expressed genes
- to stimulate human intestinal epithelial cells for cytokine secretion
- to study its effect on transcriptional responses of inflammation/respiratory burst-associated genes in mouse alveolar macrophages by customized reverse transcription (RT)-PCR based arrays
- as a substrate in β-1,3–1,4-Glucanase activity assay
Biochem/physiol Actions
Curdlan is used as a food additive in the food industry. It improves the elasticity and reduces the embrittling tendency of hydroxyapatite/chitosan scaffold, which aids in bone regeneration.
Curdlan is a (1,3)-β-glucan. It is a pathogen-associated molecular-pattern (PAMP) recognized by the receptor dectin-1. Activation of dectin-1, together with TLR2/TLR6, promotes signaling resulting in the production of pro-inflammatory cytokines, thus inducing inflammation.
Preparation Note
For gelation at 70 °C, the concentration of the sodium hydroxide should be 0.01 M.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chunju An et al.
The Journal of biological chemistry, 284(29), 19716-19726 (2009-06-03)
Serine proteinases in insect plasma have been implicated in two types of immune responses; that is, activation of prophenoloxidase (proPO) and activation of cytokine-like proteins. We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm, Manduca
K N Masihi et al.
International journal of immunopharmacology, 19(9-10), 463-468 (1998-06-24)
The effects of glucan-based immunomodulators curdlan sulfate (CRDS) and lentinan on cytokine production stimulated by lipopolysaccharide (LPS) in bacillus Calmette-Guerin (BCG)-primed mice were investigated. Pretreatment with CRDS or lentinan before LPS administration induced a striking inhibition of up to 89%
Nicola Jackson et al.
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Type B T cells recognize peptide-MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA-DM. Type A conformers
M Matsushita
Immunology letters, 26(1), 95-97 (1990-10-01)
From the results of consumption experiments of guinea pig complement, Curdlan, a (1----3)-beta-D-glucan obtained from Alcaligenes faecalis var. myxogenes IFO13140, has been found to lack the ability to activate complement when unheated or preheated at either 40 degrees C or
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