C3138
Cathepsin D from bovine spleen
lyophilized powder, ≥2.0 units/mg protein
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.32
form
lyophilized powder
Quality Level
specific activity
≥2.0 units/mg protein
mol wt
~45 kDa
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... CTSD(282883)
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Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Unit Definition
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Physical form
Lyophilized powder containing citrate buffer salts
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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