MilliporeSigma
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C1163

Sigma-Aldrich

Complement C5 deficient serum human

for complement assays

NACRES:
NA.61

Quality Level

biological source

human

form

solution

technique(s)

activity assay: suitable

UniProt accession no.

storage temp.

−70°C

Gene Information

human ... C5(727)

Related Categories

Application

Complement C5 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). Deficiency in C5 results in an impairment of hemolytic activity from both the classical and alternative pathway of the complement system. Recently, genetic research has revealed that a 153 bp deletion in exon 30 results in complete C5 deficiency. Research has also implicated C5 deficiency in a predisposition to cardiac dysfunction when cardiac injury occurs.

Biochem/physiol Actions

Complement C5 deficiency can, paradoxically, protect against certain effects of infection. Patients deficient in C5 are unusually susceptible to meningococcal infection, but have a milder course of infection. Reduced expression of tumor necrosis factor (TNF) may account for this effect.

Physical form

Supplied as a solution in PBS, pH 7.4

Analysis Note

C5 is depleted by immunoadsorption as determined by hemolytic assay.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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