C0832

Clozapine N-oxide

• Synonym(s): 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
• Empirical Formula (Hill Notation): C₁₈H₁₉ClN₄O
• CAS Number: 34233-69-7
• Molecular Weight: 342.82
• MDL number: MFCD00210190
• UNSPSC Code: 12352119
• PubChem Substance ID: 24892276
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 200
• SMILES string: C[N+]1([O-])CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: OGUCZBIQSYYWEF-UHFFFAOYSA-N

Description

General description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Application

Clozapine N-oxide has been used:

• for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
• for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
• in behavioral testing in mice and for stimulating (HEK293) cells

Biochem/physiol Actions

5-HT₂ serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

Features and Benefits

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Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 - H336
• pcodes: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves