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B9688

Sigma-Aldrich

Pizotifen

≥98% (HPLC)

Synonym(s):

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C19H21NS
CAS Number:
15574-96-6
Molecular Weight:
295.44
EC Number:
239-632-9
MDL number:
MFCD00864192
UNSPSC Code:
12352200
PubChem Substance ID:
329773323
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥8 mg/mL

originator

Novartis

storage temp.

room temp

SMILES string

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

InChI key

FIADGNVRKBPQEU-UHFFFAOYSA-N

Biochem/physiol Actions

Pizotifen is a Serotonin antagonist used for prophylaxis of migraine
Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Paul Silcocks et al.
Trials, 11, 71-71 (2010-06-18)
A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and adults have high placebo
M H Guillet et al.
Annales de dermatologie et de venereologie, 122(11-12), 777-779 (1995-01-01)
Primary erythermalgia is a rare acrosyndrome due to paroxystic arteriolar dilatation of extremities that become red and congested with warmth and burning sensation or pain. We report herein the observation of a primary erythermalgia affecting 3 degrees in the same
Arthur T Strachan et al.
Medicine and science in sports and exercise, 37(3), 389-394 (2005-03-03)
The effect of serotonin (5-HT)2C receptor blockade on the thermal response and exercise performance during exercise in a warm environment was examined. Seven endurance-trained, but not heat-acclimatized, individuals (six males and one female) performed two 40-km time trials on a
G L Briars et al.
Archives of disease in childhood, 93(7), 590-593 (2008-04-03)
To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen Retrospective case note review West Suffolk Hospital between 1999 and 2003 PATIENTS: 405 clinic attendances of 121 children receiving pizotifen treatment Rates of change
Tomasz Huć et al.
Pharmacological research, 130, 172-179 (2017-12-31)
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and
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