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Key Documents

AV45381

Sigma-Aldrich

Anti-PTPRN antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ16131, Anti-IA-2, Anti-IA-2/PTP, Anti-IA2, Anti-ICA512, Anti-Protein tyrosine phosphatase, receptor type, N, Anti-R-PTP-N

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

96 kDa

species reactivity

mouse, dog, rabbit, human, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_002837

UniProt accession no.

Q16849

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTPRN(5798)

Immunogen

Synthetic peptide directed towards the middle region of human PTPRN

Application

Anti-PTPRA (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 0.0625μg/ml.

Biochem/physiol Actions

Protein tyrosine phosphatase, receptor type N (PTPRN) is a member of protein tyrosine phosphatase (PTP) family involved in cell growth, differentiation and mitosis. PTPRN acts as an autoantigen in the sera of insulin-dependent diabetes mellitus patients and is the target of autoimmunity.

Sequence

Synthetic peptide located within the following region: EVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAE

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Bonifacio et al.
Diabetes, 50(11), 2451-2458 (2001-10-27)
Several self-antigens have been reported as targets of the autoimmune response in nonobese diabetic (NOD) mice. The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in this animal model for type 1
Huichun Liang et al.
Oncogene, 37(15), 1961-1975 (2018-01-26)
It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how this axis is negatively regulated. In this study, we demonstrated that
Tony Tiganis et al.
The Biochemical journal, 402(1), 1-15 (2007-01-24)
It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes. Although there has been much progress in defining the function of PTPs, the task of identifying substrates for

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